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What is the purpose of Mistral?
The main aim of Mistral (a product of Predict S.p.A.) is to provide technology for the early, non-invasive screening of a wide range of diseases. This is based on breath analysis, which involves the analysis of an individual's metabolic fingerprint through VOCs (Volatile Organic Compounds) in the exhaled breath.
How does the Mistral Sampler test work?
The patient takes deep, slow breaths in Mistral, using a disposable mouthpiece so that enough air and VOCs can be collected. The device collects the patient's exhaled air and ambient air, concentrating VOCs (volatile organic compounds) in two adsorbent cartridges. Once the sample is collected, it is sealed and stored at low temperatures. This keeps the collected VOCs in the best possible condition until they can be analysed.
Is patient preparation required for the examination?
The patient should be prepared very simply: eating (or drinking coffee or chewing gum) and smoking should be avoided for several hours before breath sampling to avoid possible contamination.
What is the duration of sampling with Mistral?
The sampling phase generally takes a few seconds: it involves one short and two normal exhalations to collect a sufficient volume of air and VOCs. The aim is to obtain a representative sample of endogenous VOCs.
How can volatile breath compounds be analysed?
The sample is taken to the Mistral Lab within five days of collection and analysed using a workflow of Thermal Desorption - Gas Chromatography/Mass Spectrometry (TD-GC-MS) analytical techniques. These techniques separate, identify and quantify the VOCs present.
Which molecules can be detected?
Mistral Technologies focuses on detecting volatile organic compounds (VOCs) in breath and the environment. These are organic molecules with a low molecular weight that are in the gaseous state at room temperature. Some predominant chemical classes of VOCs can be defined, such as aldehydes, ketones, esters, aromatic compounds, hydrocarbons, and halogenated compounds. Many VOCs are produced by the body as a result of cellular metabolism (e.g. acetone from fat metabolism and isoprene from cholesterol metabolism), while others are derived from the environment (e.g. benzene from air pollution).
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How long does it take to generate a report for an individual patient?
The report is returned within 2 weeks of sampling and presents the abundances of the main molecules detected, comparing them with the values of the reference population sample.
Is the confidentiality of patient data assured?
At the end of the sampling process, the cartridges are labelled with an encrypted barcode containing an identifier. This ensures that sensitive and historical data entered at an early stage remains known only to the medical staff responsible for the procedure, in compliance with current privacy regulations.
Which pathologies are the focus of Mistral investigations?
Mistral is at the centre of several clinical trials aimed at identifying the fingerprints of various oncological diseases, including prostate, colorectal, head and neck, and lung cancers, among others. Click here to browse the section on trials and projects in which Mistral is featured!
What are the minimum requirements for the use of Mistral Sampler?
It only takes a little to get started! Our device is designed to be easy and accessible to use. All you need is an internet connection (Wi-Fi or LAN), a PC (desktop or laptop) and a standard refrigeration system for storing air samples.
How can I go about learning more?
Would you like to explore Mistral contents in detail or download additional materials? Click here to get all the information you need!
How can I contact customer service?
You can contact us through the following contacts:
Fanny Binetti - 392.3111321 - fanny.binetti@predictcare.it
Leo Camporeale - 347.6417664 - leo.camporeale@predictcare.it
Where is Predict located?
Predict S.p.A. and the Mistral Lab are located in Bari (zip code 70132), Pad.105, Fiera del Levante (Viale Adriatico).
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Legal Information
Mistral is CE Marked Medical Device according to Regulation (EU) 745/2017 (MDR).
Mistral is a patented technology - European patent number 3873347.